She is currently pursuing her PhD at the same institution under the supervision of Professor Teck-Peng Loh. Khoo Yi Xin, Joycelyn received her BSc in chemistry and biological chemistry from Nanyang Technological University, Singapore in 2021. Kong Wai See, Theresa received her BSc in chemistry and biological chemistry from Nanyang Technological University, Singapore in 2021.
Her work focuses on protein functionalization, antibody–drug conjugate research and water-based synthetic methodology. She is presently working as a research officer with Professor Teck Peng Loh. She then worked as an Investor Relations representative at SillaJen (South Korea). Min Sun Kang, born in South Korea, received her BSc (2018) in chemistry from Imperial College London. Thereafter, the review shall discuss in detail each endogenous amino acid's intrinsic reactivity and selectivity aspects, and address the research effort to construct an ADC using each conjugation method. The review shall introduce and analyse the current developments in the modification of native amino acids on peptides or proteins and their applicability to ADC linker.
This review focuses on how the development of novel organic synthesis can solve the problems of traditional linker technology. Among such biomolecule conjugates, antibody–drug conjugates (ADCs) need a linker that provides a stable linkage between cytotoxic drugs and antibodies, whilst conjugating in a biologically benign, fast and selective fashion. Many fields in chemical biology and synthetic biology require effective bioconjugation methods to achieve their desired functions and activities.
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